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NICE Recommends Infliximab And Adalimumab For The Treatment Of Severe, Active Crohn's Disease
In final draft guidance published today (4 March) NICE has recommended infliximab and adalimumab as treatment options for people with severe, active Crohn's disease whose condition has not responded to conventional therapy, or who are intolerant of or have contraindications to conventional therapy...
Thiopurine Therapy For IBD Improves Quality Of Life
Patients with inflammatory bowel diseases (IBDs) such as Crohn's disease or ulcerative colitis do perceive a benefit from thiopurine treatment. A report in the open access journal BMC Gastroenterology has demonstrated improved health-related quality of life in 92 IBD patients...
Behavioral Health Registry For Pediatric Inflammatory Bowel Disease To Be Created With NIH Grant
The National Institutes of Health has awarded a two-year development grant to researchers with Hasbro Children's Hospital and the Bradley Hasbro Children's Research Center to better understand the role behavioral health plays in pediatric inflammatory bowel disease (IBD), a condition that causes chronic and painful inflammation in the gastrointestinal tract...
Protein Found To Be Key In Protecting The Gut From Infection
A signaling protein that is key in orchestrating the body's overall immune response has an important localized role in fighting bacterial infection and inflammation in the intestinal tract, according to a study by UC San Diego School of Medicine investigators, published in the journal Cell Host and Microbe...
New Guideline Identifies Major Risk Factors In The Development Of Colorectal Cancer In Children And Adults With Inflammatory Bowel Disease
Certain patients with inflammatory bowel disease (IBD), both ulcerative colitis and Crohn's disease of the colon, have an increased risk of developing colorectal cancer compared to individuals without IBD...
Distinct Demographic Profiles Between Crohn's Disease And Ulcerative Colitis
Although inflammatory bowel disease (IBD) [comprising mainly Crohn's disease (CD) and ulcerative colitis (UC)] is thought to affect about 150 000 people in the United Kingdom, the prevalence of severe IBD is not known. Mortality following hospitalization for IBD is significant but little has been reported on long-term follow-up...
Sufferers Of Crohn's Disease May Benefit From Vitamin D Supplements
A new study has found that Vitamin D, readily available in supplements or cod liver oil, can counter the effects of Crohn's disease...
Promising Probiotic Treatment For Inflammatory Bowel Disease
Bacteria that produce compounds to reduce inflammation and strengthen host defences could be used to treat inflammatory bowel disease (IBD). Such probiotic microbes could be the most successful treatment for IBD to date, as explained in a review published in the February issue of the Journal of Medical Microbiology...
GSK Exercises Option To Progress Development Of ChemoCentryx's Traficet-EN For The Treatment Of Inflammatory Bowel Diseases
GlaxoSmithKline (GSK) and ChemoCentryx, Inc. announced that GSK has exercised its option to obtain an exclusive license for further development and worldwide commercialization of Traficet-EN(TM) (CCX282-B), a specific CCR9 antagonist with the potential to offer a new approach for the treatment of inflammatory bowel diseases, including Crohn's disease...
Clinical Trial Seeks To Improve Patient Treatment For Crohn's Disease
Robarts Clinical Trials at The University of Western Ontario in London, Canada, has been awarded a 4.7 million dollar grant to conduct a randomized controlled trial evaluating treatment options for Crohn's disease. The outcome is expected to lead to a more streamlined treatment path and better disease management for patients...
Cancer/Inflamation Link Discovered By University Of Montreal
Canadian researchers have discovered a novel molecular mechanism that prevents cancer...
Cedars-Sinai IBD Expert Awarded Inaugural Endowed Chair
Marla C. Dubinsky, M.D., director of the Cedars-Sinai Pediatric Inflammatory Bowel Disease Center and one of the world's leading researchers studying the disease, has been named the Abe and Claire Levine Chair in Pediatric Inflammatory Bowel Disease. The endowed chair, presented in November, will fund continuing research to find groundbreaking new treatments for IBD...
ChemoCentryx Reports Positive PROTECT-1 Study Results For Traficet-EN(TM) At The GASTRO 2009 UEGW/WCOG Conference
ChemoCentryx, Inc., announced that Phase II/III clinical data from the Company's PROTECT-1 (the Prospective Randomized Oral Therapy Evaluation in Crohn's disease Trial) of Traficet-EN(TM) (CCX282-B) in patients with moderate-to-severe Crohn's disease demonstrated clinical efficacy with a favorable safety and tolerability profile...
Thalidomide: Solving The 50-Year-Old Puzzle
Research into the controversial drug thalidomide reveals that the mechanism through which the drug causes limb defects is the same process which causes it to damage internal organs and other tissues...
Subset Data From Two Randomized Phase 3 Trials Show TYSABRI Significantly Reduces Rates Of Hospitalization In Patients With Crohn's Disease
Elan Corporation, plc (NYSE: ELN) and Biogen Idec (NASDAQ: BIIB) announced data showing that treatment with TYSABRIВ® (natalizumab) significantly reduced the rate of hospitalization compared with placebo in patients with moderate - to - severe Crohn's disease during both induction and maintenance treatment...
Probiotic Found To Be Effective Treatment For Colitis In Mice
The probiotic, Bacillus polyfermenticus, can help mice recover from colitis, a new study has found. Mice treated with B. polyfermenticus during the non-inflammatory period of the disease had reduced rectal bleeding, their tissues were less inflamed and they gained more weight than mice that did not receive the treatment...
Biomedical Research Centre Searches For Immunological Biomarkers
Persistent inflammation and the activation of the immune system is the key pathological mechanism affecting many long-term conditions, such as rheumatoid arthritis, psoriasis, ulcerative colitis, and Crohn's disease and is the predominant mechanism underlying organ transplant rejection...
Diagnosis And Treatment Of Inflammatory Bowel Disease Should Improve Following Discovery Of Genetic Defect
New findings related to an uncommon genetic disorder may impact the diagnosis and treatment of inflammatory bowel disease (IBD), the most common chronic gastrointestinal illness in children and teens. Two million Americans have IBD which involves inflammation of the gastrointestinal tract...
Wildlife As A Source For Livestock Infections
A bacterium possibly linked to Crohn's disease could be lurking in wild animals. According to research published in the open access journal BMC Microbiology, Mycobacterium avium subspecies paratuberculosis (Map), can be transmitted between wildlife and domestic ruminants, supporting the theory of wildlife reservoirs of infection...
What Is Bowel Incontinence? What Is Fecal Incontinence? What Causes Bowel Incontinence?
Bowel incontinence, also known as fecal (UK: faecal) incontinence, is an inability to control bowel movements. The person's stools (feces) leak from the rectum uncontrollably. Bowel incontinence can vary in severity from passing a small amount of feces when breaking wind, to total loss of bowel control...
What Is Ulcerative Colitis? What Causes Ulcerative Colitis?
Ulcerative colitis is a fairly common chronic (long-term) disease that causes inflammation of the colon (the large intestine). It is a form of inflammatory bowel disease that has some similarity to Crohn's disease, a related disorder. The colon - or large intestine - removes nutrients form undigested food and gets rid of waste products through the rectum and anus when we pass feces (stools)...
Antimicrobial Antibodies In Celiac Disease: Trick Or Treat?
Anti-microbial antibody formation has been reported in celiac disease. Relatively high positivity rates were observed for the conventional antibodies, for example, ASCA, anti-OmpW, and anti-I2, and they were known to decrease after a successful gluten free-diet...
FDA: Cancer Warnings Required For TNF Blockers
The U.S. Food and Drug Administration is requiring stronger warnings in the prescribing information for a class of drugs known as TNF blockers...
Predictors Of Disease Behavior Change In Crohn's Disease
Using the Vienna classification system, it has been shown in clinic-based cohorts that there can be a significant change in disease behavior over time, whereas disease location remains relatively stable. Clinical and environmental factors as well as medical therapy might be relevant in predicting disease behavior change in patients with CD...
What Is Diarrhea? What Causes Diarrhea?
Diarrhea is the frequent passing of loose or watery stools. Acute diarrhea, which is a common cause of death in developing countries, appears rapidly and may last from five to ten days. Chronic diarrhea lasts much longer and is the second cause of childhood death in the developing world. Diarrhea is sometimes accompanied by abdominal cramps or fever...
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