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ZenBio Licenses An Important Cell Line From Harvard To Drive Metabolic Disease Research
ZenBio announce that they will be a commercial source for the popular murine 3T3-L1 cell line, which has been fundamental in metabolic disease research for 30 years. Originally derived from Swiss mouse embryo tissue by Dr...
Research Identifies New Mechanism Regulating Embryonic Development
A Princeton University-led research team has discovered that protein competition over an important enzyme provides a mechanism to integrate different signals that direct early embryonic development. The work suggests that these signals are combined long before they interact with the organism's DNA, as was previously believed, and also may inform new therapeutic strategies to fight cancer...
Scientists' Understanding Of Limb Growth Altered By Roving 'Sonic Hedgehog' Gene
Sonic hedgehog, a gene that plays a crucial rule in the positioning and growth of limbs, fingers and toes, has been confirmed in an unexpected place in the embryos of developing mice - the layer of cells that creates the skin. Named for a video game character, Sonic hedgehog describes both a gene and the protein it produces in the body...
Intentional Variation Increases Result Validity In Mouse Testing
For decades, the traditional practice in animal testing has been standardization, but a study involving Purdue University has shown that adding as few as two controlled environmental variables to preclinical mice tests can greatly reduce costly false positives, the number of animals needed for testing and the cost of pharmaceutical trials...
ARS Study Provides A Better Understanding Of How Mosquitoes Find A Host
The potentially deadly yellow-fever-transmitting Aedes aegypti mosquito detects the specific chemical structure of a compound called octenol as one way to find a mammalian host for a blood meal, Agricultural Research Service (ARS) scientists report...
Malaria In Pregnant Women : A First Step Towards A New Vaccine
By managing to express the protein that enables red blood cells infected with the malaria agent Plasmodium falciparum to bind to the placenta and by deciphering its molecular mechanisms, a team of researchers from CNRS and the Institut Pasteur has taken an important first step in the development of a vaccine against pregnancy-associated malaria. Their work was published in the journal PNAS...
Dependence Receptors : A New Weapon To Inhibit Tumors?
The interaction of a ligand (Neurotrophine-3) and its dependence receptor (TrkC) constitutes a novel mechanism for tumor control in pediatric cancers such as neuroblastoma, and may also be important to the inhibition of other cancers such as breast cancer...
Designer Nano Luggage To Carry Drugs To Diseased Cells
For the first time, scientists have succeeded in growing empty particles derived from a plant virus and have made them carry useful chemicals. The external surface of these nano containers could be decorated with molecules that guide them to where they are needed in the body, before the chemical load is discharged to exert its effect on diseased cells...
Biochemist Researching Computer Models Of Protein Structure That Help High School, College Students
An award from the National Science Foundation will boost a Kansas State University professor's contribution to the study of proteins while also helping college and high school science teachers learn more about computational and structural biology. Jianhan Chen, an assistant professor of biochemistry, is receiving more than $670,000 as a CAREER Award from the National Science Foundation...
New Method To Grow Arteries Could Lead To 'Biological Bypass' For Heart Disease
A new method of growing arteries could lead to a "biological bypass" - or a non-invasive way to treat coronary artery disease, Yale School of Medicine researchers report with their colleagues in the April issue of Journal of Clinical Investigation. Coronary arteries can become blocked with plaque, leading to a decrease in the supply of blood and oxygen to the heart...
The Potential For Using Algae To Produce Human Therapeutic Proteins
Pharmaceutical companies could substantially reduce the expense of costly treatments for cancer and other diseases produced from mammalian or bacterial cells by growing these human therapeutic proteins in algae - rapidly growing aquatic plant cells that have recently gained attention for their ability to produce biofuels...
Finding New Ways To Disarm Deadly South American Hemorrhagic Fever Viruses
New World hemorrhagic fevers are emerging infectious diseases found in South America that can cause terrible, Ebola-like symptoms. Current treatments are expensive and only partially effective...
New Research Shows Immune Cells Use Bungee Of Death To Kill Dangerous Cells
Immune cells ensnare dangerous cells that are on the run with a bungee-like nanotube, according to research published in the Proceedings of the National Academy of Sciences. The study, by researchers from Imperial College London, shows that natural killer (NK) cells use this bungee to destroy cells that could otherwise escape them...
Scientists Shed New Light On How Retina's Hardware Is Used In Color Vision
Biologists at New York University and the University of WГѓВјrzburg have identified, in greater detail, how the retina's cellular hardware is used in color preference. The findings, published in the latest issue of the Proceedings of the National Academy of Sciences (PNAS), enhance our understanding of how eyes and the brain process color...
Stem Cells Of Humans And Mice Differ More Strongly Than Suspected: New Study Calls Research Factors Into Question
They are considered to be the most important model organism for research into human biology: mice may look totally different, but they are in many ways similar to Homo sapiens on a fundamental level. For instance, an impressive 99 per cent of the mouse genes are matched by a corresponding sequence in the human genome...
Unselfish Molecules May Have Helped Give Birth To The Genetic Material Of Life
One of the biggest questions facing scientists today is how life began...
Like Little Golden Assassins, 'Smart' Nanoparticles Identify, Target And Kill Cancer Cells
Another weapon in the arsenal against cancer: Nanoparticles that identify, target and kill specific cancer cells while leaving healthy cells alone. Led by Carl Batt, the Liberty Hyde Bailey Professor of Food Science, the researchers synthesized nanoparticles shaped something like a dumbbell made of gold sandwiched between two pieces of iron oxide...
Exploring Echinacea's Enigmatic Origins
An Agricultural Research Service (ARS) scientist is helping to sort through the jumbled genetics of Echinacea, the coneflower known for its blossoms - and its potential for treating infections, inflammation, and other human ailments...
Science World Charmed By Snake Venom
The King Cobra continues to weave its charm with researchers identifying a protein in its venom with the potential for new drug discovery and to advance understanding of disease mechanisms. The novel protein named haditoxin has been described in the prestigious Journal of Biological Chemistry (March 12, 2010)...
HIV Hides In Bone Marrow Say Researchers
Researchers in the US have discovered that a latent form of HIV hides in progenitor cells in bone marrow, avoids detection by the immune system and retains the ability to reproduce and spread when the coast is clear (eg when treated people stop taking anti-HIV drugs)...
Government Of Canada Completes Assessments For 14 Additional Substances Under The Chemicals Management Plan
The Honourable Leona Aglukkaq, Minister of Health, and the Honourable Jim Prentice, Minister of the Environment, released the final screening assessment reports, and, where applicable, the proposed risk management approach documents for 14 substances assessed in Batch 7 of the Chemicals Management Plan. "Canada continues to be at the forefront of chemicals management," said Minister Aglukkaq...
Max Planck Scientists Develop A Fingerprint For Genes: New Strategy To Play Major Role In Research On Human Diseases
Cells may not have a mouth, but they still need to ingest substances from the external environment. If this process - known as endocytosis - is affected, it can lead to infectious diseases or cardio-vascular diseases, cancer, Huntington's and diabetes...
Ritalin Boosts Learning By Increasing Brain Plasticity
Doctors treat millions of children with Ritalin every year to improve their ability to focus on tasks, but scientists now report that Ritalin also directly enhances the speed of learning. In animal research, the scientists showed for the first time that Ritalin boosts both of these cognitive abilities by increasing the activity of the neurotransmitter dopamine deep inside the brain...
In Stanford Study Mathematical Innovation Turns Blood Draw Into Information Gold Mine
Scientists at the Stanford University School of Medicine have devised a software algorithm that could enable a common laboratory device to virtually separate a whole-blood sample into its different cell types and detect medically important gene-activity changes specific to any one of those cell types...
New Sensor Array Detects Single Molecules For The First Time
MIT chemical engineers have built a sensor array that, for the first time, can detect single molecules of hydrogen peroxide emanating from a single living cell...
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